Case Study: Neural Growth Factor Therapy for Spinal Cord Injury

Patient Information

• Name: Jian Zhang
• Diagnosis: Spinal Cord Injury
• Date of Birth: January 1, 1992
• Gender: Male
• Country: China

Admission & Treatment
On December 12, 2010, Mr. Jian Zhang was admitted to Beijing Puhua International Hospital following a spinal cord injury and a previous cervical vertebrae operation. Upon admission, he exhibited complete paralysis of his arms and legs, loss of sensation below the C-5 plane, elevated body temperature (37.8℃), and pressure sores.

Mr. Zhang received Neural Growth Factor Therapy, combined with stem cell activation and proliferation program, along with rehabilitation training during his one-month stay.

Clinical Outcome
One month post-admission, Mr. Zhang demonstrated significant improvements in his neurological status:

• Regained sensation on the radial side of both arms
• Lowered neurological plane of sensation bilaterally (left: fourth intercostal plane, right: third intercostal plane)
• Normalized body temperature (37.2℃)

His pressure sores also showed signs of improvement.

All healthcare professionals at BPIH anticipate further progress in Mr. Jian Zhang's recovery.

Case Study: Spinal Cord Reconstruction Surgery for Spinal Cord Injury

Patient Information

• Name: Aditya
• Date of Birth: January 1, 1993
• Gender: Male
• Country: Nepal

Diagnosis

• Spinal Cord Injury (SCI)

Medical History
Admitted to Beijing Puhua International Hospital six months post-motor vehicle accident with complaints of limbs mobility disorder.

Preoperative Status

• Alert and oriented, with fluent speech and normal visual acuity.
• Equal, round pupils with brisk response to light; intact ocular movements and pharyngeal reflex.
• Soft and supple neck, no deviation noted with the uvula.
• Muscle strength: 5/5 in upper limbs, slightly low muscular tension in lower limbs.
• Pain sensation absent below bilateral inguinal level (3 cm).
• Incision scar present on lumbar back; bladder stoma noted in abdomen.

Surgical Intervention

• Intra-spinal exploration via post-midline approach was performed on May 30, 2013.
• Postoperative management included fluid infusion, neural nutrition, hemostasis, anti-secretory, and anti-infective medications.

Postoperative Status (21 days post-surgery)

• Alert with stable vital signs and clear speech; pupils equal, round, and responsive to light.
• Limb movements unchanged from preoperative status.
• Sensation improved in right lower limb, sensory level moved down to 3.0 cm above the knee.
• Incision well-healed.

Treatment Plan

• Ongoing rehabilitation therapy and traditional medicine support alongside postoperative care.

Case Study: Spinal Cord Reconstruction Surgery and Neural Growth Factor Therapy for Complete Spinal Cord Injury

Patient Information:

• Name: Aboubakr Mohamed
• Date of Birth: December 7, 1976
• Gender: Male
• Country: Egypt

Diagnosis: Traumatic complete spinal cord injury ( SCI) at the thoracic level (T5)

History:
Mr. Mohamed sustained a gunshot injury to his spinal cord in April 2014, resulting in immediate paralysis below the T5 level. He underwent stem cell injection therapy elsewhere but showed no significant improvement. In September 2015, he traveled to Beijing Puhua International Hospital for advanced Spinal Cord Reconstruction Surgery (SCRS) and Neural Growth Factor Therapy (NGFT).

Medical Condition Prior to Intervention:

• Sensations: Absent below T5
• Motor function: Non-ambulatory

Interventions:

Spinal Cord Reconstruction Surgery:
On September 18, 2015, Mr. Mohamed underwent SCRS. The procedure involved:

1. Clearing away spinal cord scars and separating adhesions.
2. Bridging the injured spinal cord segments using peripheral nerve grafts and a biological tube implant.
3. Local injection of neural growth factor (NGF) to promote axonal regeneration and remyelination.

Neural Growth Factor Therapy:
On September 28, 2015, Mr. Mohamed received an additional dose of NGF via lumbar puncture to reinforce the effects of the previous intervention.

Post-Intervention Progress:
Three months post-intervention, Mr. Mohamed reported experiencing sensations in his lower extremities for the first time since his injury. He was able to walk with the assistance of a walker, demonstrating significant functional improvement compared to his pre-operative status.

This case study highlights the potential of SCRS and NGFT in promoting functional recovery following complete spinal cord injury. However, it is crucial to remember that individual outcomes may vary, and further research is required to optimize these therapeutic approaches.

Disclaimer: Results may not be representative or predictive of all cases.

Case Study: Spinal Cord Reconstruction Surgery for Spinal Cord Injury

Patient Information:

• Name: Alameni Asem
• Date of Birth: January 1, 1983
• Gender: Male
• Country: Liberia
• Diagnosis: Spinal Cord Injury (SCI) at T9-11 with paraplegia

Medical History:
In April 2010, Mr. Alameni Asem fell from the second floor, resulting in a spinal cord injury at the thoracic levels T9-11. He underwent a reduction operation with posterior fixation by screws and subsequent rehabilitation therapy.

Initial Presentation (December 2010):
Upon admission to Beijing Puhua International Hospital, Mr. Asem was alert and oriented with normal breathing, speech, cognition, and upper limb movements. However, he exhibited paraplegia below the level of his umbilicus with:

• Loss of sensation to pain and temperature
• No voluntary movement in lower limbs
• Urinary and fecal incontinence

Treatment Course (21 days):
Mr. Asem underwent Spinal Cord Reconstruction Surgery along with Neural Growth Factor Therapy, Traditional Chinese Medicine, and Rehabilitation Therapy.

Post-Treatment Progress:
During his hospitalization, Mr. Asem responded positively to the treatments:

• Sensation improved from umbilicus level to hip level
• Experienced an erection one morning after the first injection of neural growth factor
• Felt pain in his foot during removal of IV needle after the second injection
• Moved toes voluntarily on the third occasion and could lift feet lightly

Current Status:
Following spinal cord reconstruction treatment, Mr. Alameni Asem has regained sensation in his legs and can move them slightly.

Prognosis:
All medical personnel involved anticipate further improvements in Mr. Asem's condition with continued rehabilitation efforts.

Disclaimer: The outcome of this case may not be indicative of all patients undergoing similar treatments. Each patient's response to treatment is unique and depends on various factors including the severity and location of injury, time since injury, age, and overall health status.